RELAÇÃO E EFEITOS BIOQUÍMICO-NUTRICIONAIS SOBRE O RETARDO DA MATURIDADE SEXUAL EM BOVINOS -/- -/- Emanuel Isaque Cordeiro da Silva -/- Departamento de Agropecuária – IFPE Campus Belo Jardim -/- [email protected] ou [email protected] -/- WhatsApp: (82)98143-8399 -/- -/- 12. RETARDO DA MATURIDADE SEXUAL -/- -/- Nos animais em crescimento, as deficiências em qualquer dos nutrientes: proteína, energia, macro ou microminerais, vitaminas e aporte hídrico, geram inibição das sínteses de proteínas específicas como os fatores de crescimento. Neste tipo de situação, as taxas (...) de ganho de peso e o desenvolvimento dos diferentes segmentos do trato reprodutivo se alteram. Os animais atrasam a idade a que chegam à puberdade, atrasando a entrada na vida produtiva como animais aptos a se reproduzir. O quadro de atraso à puberdade ocasiona atraso na idade a que se apresenta o primeiro parto, fator responsável por grande parte das falhas na eficiência reprodutiva. Sem dúvida, aspectos nutricionais são os maiores limitantes no crescimento e na maturidade reprodutiva, sendo assim, esse trabalho têm como cunho a apresentação de alguns destes fatores: -/- 12.1 Relação Energia:Proteína -/- A maturidade sexual relaciona-se com um consumo adequado de energia e com a obtenção de um peso corporal adequado; o crescimento depende, em grande medida, da ingestão abundante de elementos energéticos. Uma ração deficiente em energia diminui a velocidade de crescimento, reduz a produção de leite, retarda a puberdade, reduz a fertilidade e diminui a resistência às doenças e ao parasitismo. -/- Uma das causas mais comuns da baixa fertilidade e do atraso da maturidade sexual nas vacas leiteiras é a falta de energia em relação às necessidades do animal ou um balanço de energia negativo; além disso, este atraso no início tardio da maturidade sexual diminui o tempo de vida durante o qual os animais têm uma reprodução ativa. -/- A falta de energia na ração pode ser causada por um consumo insuficiente de alimentos ou por uma baixa digestibilidade de seus componentes (dieta de baixa qualidade) e, por um teor elevado de umidade na dieta. O baixo consumo de energia é normalmente o resultado de restrições alimentares. Em qualquer uma das situações, a falta de energia impede o animal de expressar seu potencial genético de produção e o problema complica-se se, por sua vez, existe deficiência em proteínas, minerais e vitaminas. -/- Como referenciado anteriormente, a energia têm papel fundamental em todos os mecanismos fisiológicos do animal, seja para a reprodução, fornecimento de leite ou para produção de carne, uma vez que possui relação direta com as mitocôndrias celulares. A energia é considerada um tipo de gordura, e possui relação direta com o sistema reprodutivo da vaca. Para a produção de leite, uma vaca pode utilizar suas reservas de gordura e transformá-las em leite, isto é, a cada quilo de gordura corporal pode-se obter de 7 a 9 quilos de leite. O fornecimento de energia têm como fator a categoria animal, o sistema produtivo, a idade etc. logo, a administração de energia deve obedecer os parâmetros de 1,75 a 1,25 Mcal/kg do alimento fornecido, seja matéria seca, volumoso ou ração concentrada. Vale frisar novamente que os níveis de energia administrada devem ser altos (1,72 Mcal/kg) para as vacas no início da lactação e deve-se diminuir gradativamente conforme chega o final da lactação, chegando a 1,54 Mcal/kg ou menos. No caso de prevenção contra o retardamento dos animais à idade reprodutiva, os níveis de energia para as bezerras de 0-3 meses com ± 150 kg deve ser de 1,70 Mcal/kg de MS para mantença e de 1,06 Mcal para ganho de peso diário; para bezerras com idade entre 6-12 meses e um peso de ± 250 kg o nível de energia deve ser de 1,54 Mcal para mantença e de 0,97 para ganho; por fim, para bezerras chegando a categoria de novilhas (> 12 meses) o ideal é o fornecimento de 1,39 Mcal para mantença e de 0,81 Mcal para ganho. Os alimentos que mais fornecem energia são o sebo, a gordura protegida, o milho, etc. -/- O efeito da proteína da dieta na reprodução é complexo. Em geral, quantidades inadequadas de proteína na dieta reduzem a produção de leite e o desempenho reprodutivo (maturidade sexual). Deficiências de proteínas diminuem os níveis de proteínas de reserva ou de transporte no sangue, fígado e músculos o que predispõe o animal a várias doenças que podem levar a não manifestação da maturidade sexual ou mesmo a morte. -/- Há tipos de proteínas como a PB (proteína bruta), a PDR (proteína degradada no rúmen), proteína metabolizável entre outras, ambas possuem relação com a PB e são primordiais no entendimento da nutrição de ruminantes. Os níveis de PDR se forem baixos mostra uma boa população microbiana presente no rúmen do animal, esse compartimento que se desenvolve conforme a ingestão de alimentos concentrados. -/- Para que se possa prevenir o retardamento dos animais à maturidade sexual, deve-se estar atentos aos níveis de proteína que se administra aos animais, em especial para as bezerras que entrarão logo na puberdade estando aptas para se reproduzir. Contudo, o tipo e a quantidade de proteína se limita a fatores como os ingredientes da ração, método alimentar utilizado na propriedade e o potencial produtivo do lote que se maneja. Sendo assim, os níveis oscilam conforme a categoria, idade e peso como demonstra na tabela 1, que traz os níveis ideias de proteína que devem estar presentes na alimentação das bezerras conforme idade e peso médio das mesmas. -/- Tabela 1: Exigências de proteína em bezerras e novilha -/- Nutriente 3-6 meses (± 150 kg) 6-12 meses (± 250 kg) > 12 meses (± 400 kg) -/- PB % 16 12 12 -/- PDR % 8,2 4,3 2,1 -/- Fonte: TEIXEIRA, 1997. -/- Para que as bezerras entrem na maturidade sexual sem atraso ou quaisquer problema, é ideal que a ração que viera ser fornecida para as mesmas possuam uma quantidade básica de 22% de PB presente na composição. Os alimentos mais proteicos são os de origem animal como a farinha de sangue, de penas etc., porém sua administração deve ser limitada. Sendo assim, a tabela 2 traz os possíveis melhores alimentos a serem ofertados aos animais e sua quantidade diária para que se possa suprir os requerimentos dos animais e prevenir o retardamento sexual ou qualquer outro problema reprodutivo que tenha relação nutricional. -/- Tabela 2: Alimentos proteicos e quantidades ideais para bovinos -/- Alimento PB% Quantidade % da mistura ou kg/cab./dia -/- Caroço de algodão 21 ± 50% da mistura da ração (1 kg = 0,5 kg de caroço) -/- Farelo de glúten de milho 23 Pode substituir o volumoso (máximo 3,5 kg/cab./dia) -/- Grão de soja 38 ± 20% da mistura (1 kg = 0,2 kg de grão) ou no máximo 2,5-3,5 kg/cab./dia -/- Farelo de algodão 41 ± 30-40% da mistura (1 kg = 0,3-0,4 kg de farelo) ou no máximo 4,5 kg/cab./dia -/- Fonte: TEIXEIRA, 1997. -/- A Ureia e outras substâncias que contêm nitrogênio não proteico (NNP) podem ser utilizadas pelos microrganismos do rúmen para a produção de proteínas bacterinas. Em geral, a utilização da NNP não é recomendada, exceto em situações especiais de alimentação e sob controle técnico, uma vez que um manejo inadequado, nomeadamente de excessos de consumo, pode provocar intoxicações com efeitos letais (ROIG, 2003; FERGUSON et al., 1989). É claro que as fontes de NNP não possuem aminoácidos e que muitos deles são essenciais e não são sintetizados pela microbiota ruminal. -/- Alguns autores argumentam que o nitrogênio não proteico (NNP) como a ureia, pode ser muito bem utilizado desde que não exceda um terço do total de nitrogênio na dieta diária ou 3% da ração de grãos de cereais e após adaptação gradual de, pelo menos, três semanas. A boa utilização da ureia nos ruminantes depende da ração conter pelo menos 75% de nutrientes digestíveis totais NDT, disponibilidade suficiente de amido e de CNE para converter o nitrogênio da ureia em proteína microbiana e quando o teor de proteína verdadeira da ração não for inferior a 12% (ROIG, 2003). -/- 12.2 Minerais (K e I) -/- Um excesso de potássio no sangue ocorre quando o consumo excede a capacidade do rim de o eliminar, provocando um atraso na maturidade sexual, ciclos sexuais irregulares e baixa natalidade; também interfere na absorção intestinal do magnésio, dificultando a absorção e o metabolismo do cálcio, magnésio e sódio; geralmente afeta fêmeas de alta produção leiteira (com o leite é excretado muito magnésio). -/- No macho, o excesso de potássio diminui a fecundidade, altera as vesículas seminais e influencia a composição espermática. Na fêmea prejudicaria os ciclos sexuais (duração e intensidade). -/- A excreção de íons de potássio diminui quando se ingere pouca quantidade deste elemento e de sódio, e quando há acidose aguda ou insuficiência das glândulas adrenais. -/- O potássio é um elemento de muitas funções no metabolismo animal e participa de múltiplos mecanismos fisiológicos, dentre eles o reprodutivo. Sendo assim, é importante o criador estar atento sobre a administração do mineral na alimentação das bezerras que vão entrar para a maturidade sexual. De forma geral, é indicado fornecer matéria seca que contenha K na ordem de 0,6 a 1% da composição do alimento. Em média, uma vaca de 600 kg que produz 15 kg de leite ingira cerca de 230 gramas desse mineral diariamente. -/- Em crescimento, a função tireoide tem um papel protetor da sexualidade e estimula a puberdade por suas relações com as funções hipofisária e ovariana, atuando como sensibilizador da gônada para o aparecimento do estro; sendo, na fêmea sinérgico com a FSH. Uma deficiência na produção de hormonas da tireoide induzirá uma redução na troca de energia e na liberação de calor corporal, ou seja, ocorre uma diminuição no metabolismo basal do -/- As iodo-proteínas ou tireoproteínas (T3 e T4) beneficiam o crescimento e a secreção láctea, no macho estimulam a puberdade (maturidade sexual) e são gametogênicas (a hipófise é estimulada pela tiroxina e a vitamina A). -/- Para se livrar do atraso e da desordem da administração dos animais e do cronograma da fazenda, o proprietário deve atentar ao fornecimento adequado de I que varia entre 0,34 e 0,88 mg/kg de MS. -/- As formas de prevenção por parte desses minerais poderá ser manejada através dos alimentos, da água ou via suplementação mineral injetável. Por fim, o criador poderá ficar tranquilo e ter seu cronograma estabelecido sendo posto e prática e obtendo êxito no plantel. -/- -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- -/- BARRENHO, Gonçalo José Pinheiro. Nutrição e fertilidade em bovinos de leite. 2016. Dissertação de Mestrado. Universidade de Évora. -/- BINDARI, Yugal Raj et al. Effects of nutrition on reproduction-A review. Adv. Appl. Sci. Res, v. 4, n. 1, p. 421-429, 2013. -/- BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. -/- CASTILLO-BADILLA, Gloriana et al. Efecto de la edad al primer parto sobre parámetros productivos en vacas Jersey de Costa Rica. Agronomía Mesoamericana, v. 24, n. 1, p. 177-187, 2013. -/- DEHNING, R. Interrelaciones entre nutrición y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. -/- DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. -/- DIAS, Juliano Cesar et al. Alguns aspectos da interação nutrição-reprodução em bovinos: energia, proteína, minerais e vitaminas. PUBVET, v. 4, p. Art. 738-743, 2010. -/- FERGUSON, James D.; CHALUPA, William. Impact of protein nutrition on reproduction in dairy cows. Journal of dairy science, v. 72, n. 3, p. 746-766, 1989. -/- GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. -/- GRANJA, Yury Tatiana; CERQUERA, Jefferson; FERNÁNDEZ, Omar. Factores nutricionales que interfieren en el desempeño reproductivo de la hembra bovina. Revista Colombiana de Ciencia Animal, v. 4, n. 2, p. 458-472, 2012. -/- MAAS, John. Relationship between nutrition and reproduction in beef cattle. The Veterinary Clinics of North America. Food Animal Practice, v. 3, n. 3, p. 633-646, 1987. -/- NOGUEIRA, E. et al. Nutrição aplicada à reprodução de bovinos de corte. Embrapa Pantanal-Capítulo em livro científico (ALICE), 2015. -/- PASA, Camila. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2011. -/- ROIG, C. Alimentación del ganado caprino. Informe técnico: PROGANO-INTA. Colonia Benítez, Chaco, Argentina, 2003. -/- SARTORI, Roberto; GUARDIEIRO, Monique Mendes. Fatores nutricionais associados à reprodução da fêmea bovina. Revista Brasileira de Zootecnia, v. 39, p. 422-432, 2010. -/- SHORT, Robert E.; ADAMS, D. C. Nutritional and hormonal interrelationships in beef cattle reproduction. Canadian Journal of Animal Science, v. 68, n. 1, p. 29-39, 1988. -/- TEIXEIRA, J. C.; TEIXEIRA, LFAC. Alimentação de bovinos leiteiros. FAEPE, Lavras, 1997. -/- . (shrink)

Knowledge-how often appears to be more difficult to transmit by testimony than knowledge-that and knowledge-wh. Some philosophers have argued that this difference provides us with an important objection to intellectualism—the view that knowledge-how is a species of knowledge-that. This article defends intellectualism against these testimony-based objections.

In this paper I develop three different arguments against the thesis that knowledge-how is a kind of knowledge-that. Knowledge-that is widely thought to be subject to an anti-luck condition, a justified or warranted belief condition, and a belief condition, respectively. The arguments I give suggest that if either of these standard assumptions is correct then knowledge-how is not a kind of knowledge-that. In closing I identify a possible alternative to the standard Rylean and intellectualist accounts of knowledge-how. This alternative view (...) illustrates that even if the arguments given here succeed it might still be reasonable to hold that knowing how to do something is a matter of standing in an intentional relation to a proposition other than the knowledge-that relation. (shrink)

How should intellectualists respond to apparent Gettier-style counterexamples? Stanley offers an orthodox response which rejects the claim that the subjects in such scenarios possess knowledge-how. I argue that intellectualists should embrace a revisionary response according to which knowledge-how is a distinctively practical species of knowledge-that that is compatible with Gettier-style luck.

It is often said that ‘what it is like’-knowledge cannot be acquired by consulting testimony or reading books [Lewis 1998; Paul 2014; 2015a]. However, people also routinely consult books like What It Is Like to Go to War [Marlantes 2014], and countless ‘what it is like’ articles and youtube videos, in the apparent hope of gaining knowledge about what it is like to have experiences they have not had themselves. This article examines this puzzle and tries to solve it by (...) appealing to recent work on knowing-wh ascriptions. In closing I indicate the wider significance of these ideas by showing how they can help us to evaluate prominent arguments by Paul [2014; 2015a] concerning transformative experiences. (shrink)

This article examines the method of reflective equilibrium (RE) and its role in philosophical inquiry. It begins with an overview of RE before discussing some of the subtleties involved in its interpretation, including challenges to the standard assumption that RE is a form of coherentism. It then evaluates some of the main objections to RE, in particular, the criticism that this method generates unreasonable beliefs. It concludes by considering how RE relates to recent debates about the role of intuitions in (...) philosophy. (shrink)

Hawley introduced the idea of the client's perspective on knowledge, which she used to illuminate knowing-how and cases of epistemic injustice involving knowing-how. In this paper, I explore how Hawley's idea might be used to illuminate not only knowing-how, but other forms of knowledge that, like knowing-how, are often claimed to be distinct from mere knowing-that, focusing on the case studies of moral understanding and ‘what it is like’-knowledge.

This chapter explores the relationship between knowing-how and skill, as well other success-in-action notions like dispositions and abilities. I offer a new view of knowledge-how which combines elements of both intellectualism and Ryleanism. According to this view, knowing how to perform an action is both a kind of knowing-that (in accord with intellectualism) and a complex multi-track dispositional state (in accord with Ryle’s view of knowing-how). I argue that this new view—what I call practical attitude intellectualism—offers an attractive set of (...) solutions to various puzzles concerning the connections between knowing-how and abilities and skills to perform intentional actions. (shrink)

Paul (2014, 2015a) argues that one cannot rationally decide whether to have a transformative experience by trying to form judgments, in advance, about (i) what it would feel like to have that experience, and (ii) the subjective value of having such an experience. The problem is if you haven’t had the experience then you cannot know what it is like, and you need to know what it is like to assess its value. However, in earlier work I argued that ‘what (...) it is like’-knowledge comes in degrees, and I briefly suggested that, consequently, some instances of Paul’s argument schema might commit a fallacy of equivocation. The aim of this paper is to further explore and strengthen this objection by, first, offering a new argument—the modelling argument—in support of it, and then by evaluating a range of replies that might be given to this objection on Paul’s behalf. I conclude that each reply either fails or, at best, only partially succeeds in defending some but not all instances of Paul’s argument schema. In closing, I consider how we might revise Paul’s concepts of transformative experiences and choices in response to this conclusion. (shrink)

Is there a successful regress argument against intellectualism? In this article I defend the negative answer. I begin by defending Stanley and Williamson's (2001) critique of the contemplation regress against Noë (2005). I then identify a new argument – the employment regress – that is designed to succeed where the contemplation regress fails, and which I take to be the most basic and plausible form of a regress argument against intellectualism. However, I argue that the employment regress still fails. Drawing (...) on the previous discussion, I criticise further regress arguments given by Hetherington (2006) and Noë (2005). (shrink)

What is the relationship between the linguistic properties of knowledge-how ascriptions and the nature of knowledge-how itself? In this chapter I address this question by examining the linguistic methodology of Stanley and Williamson (2011) and Stanley (2011a, 2011b) who defend the intellectualist view that knowledge-how is a kind of knowledge-that. My evaluation of this methodology is mixed. On the one hand, I defend Stanley and Williamson (2011) against critics who argue that the linguistic premises they appeal to—about the syntax and (...) semantics of knowledge-how and knowledge-wh ascriptions—do not establish their desired conclusions about the nature of knowledge-how itself. But, on the other hand, I also criticize the role that linguistic considerations play in Stanley’s (2011a) response to apparent Gettier-style counterexamples to intellectualism. (shrink)

A proposed plan to rescue US biomedical research from its current ‘malaise’ will not be effective as it misdiagnoses the root cause of the disease.

There is an intimate relationship between our experiences and our knowledge of what it is like to have those experiences. For having an experience of Φ-ing is clearly an important way of coming to know what it is Φ, and some philosophers have even suggested that it is the only way of coming to possess such knowledge. But despite this intimate connection, we often possess WIL-knowledge after any generating experience has ended. How is this possible? One popular suggestion, roughly following (...) David Lewis, is that one retains knowledge of what it is like to Φ in virtue of retaining abilities to imagine, remember, and recognise experiences of Φ-ing. In this chapter, my aim is to clarify and update this retention hypothesis, by showing how it is independent from Lewis’ ability hypothesis (according to which WIL-knowledge is identified with these abilities), and by identifying and resolving certain ambiguities involved in interpreting Lewis’ three ability conditions, especially the ability to imagine condition. I also explore issues concerning the relative priority of these three conditions, and I argue that there is a good sense in which the ability to imagine condition is the most important of these conditions with respect to how we conceptualise and ascribe WIL-knowledge. (shrink)

This commentary suggests that the ongoing malaise of biomedical research results from adopting a doctrine that is incompatible with the principles of creative scientific discovery and thus should be treated as a mental rather than somatic disorder. I overview the progression of the malaise, outline the doctrine and the history of its marriage to science, formulate the diagnosis, justify it by reviewing the symptoms of the malaise, and suggest how to begin to cure the disease.

This chapter examines some key developments in discussions of the social dimensions of knowing-how, focusing on work on the social function of the concept of knowing-how, testimony, demonstrating one's knowledge to other people, and epistemic injustice. I show how a conception of knowing-how as a form of 'downstream knowledge' can help to unify various phenomena discussed within this literature, and I also consider how these ideas might connect with issues concerning wisdom, moral knowledge, and moral testimony.

Many philosophers accept a view – what I will call the intuition picture – according to which intuitions are crucial evidence in philosophy. Recently, Williamson has argued that such views are best abandoned because they lead to a psychologistic conception of philosophical evidence that encourages scepticism about the armchair judgements relied upon in philosophy. In this paper I respond to this criticism by showing how the intuition picture can be formulated in such a way that: it is consistent with a (...) wide range of views about not only philosophical evidence but also the nature of evidence in general, including Williamson's famous view that E = K; it can maintain the central claims about the nature and role of intuitions in philosophy made by proponents of the intuition picture; it does not collapse into Williamson's own deflationary view of the nature and role of intuitions in philosophy; and it does not lead to scepticism. (shrink)

Often philosophers have reason to ask fundamental questions about the aims, methods, nature, or value of their own discipline. When philosophers systematically examine such questions, the resulting work is sometimes referred to as “metaphilosophy.” Metaphilosophy, it should be said, is not a well-established, or clearly demarcated, field of philosophical inquiry like epistemology or the philosophy of art. However, in the late 20th and early 21st centuries there has been a great deal of metaphilosophical work on issues concerning the methodology of (...) philosophy in the analytic tradition. This article focuses on that work. (shrink)

This paper addresses the field of economic measurements of the value of assets, carried out by the methods of independent expert evaluation. The mathematical principles of application, within a comparative methodical approach, of additive and multiplicative models for correcting the cost of single indicator of compared objects have been considered. The differences of mathematical basis of the compared models were analyzed. It has been shown that the ambiguity in the methodology of correction procedure requires studying the advantages and disadvantages of (...) known models, as well as the justification and elaboration of recommendations for their application. Possible forms of correction representation using several alternative units of measurement have been defined; formulas for their interconnection have been built. Analytic expressions have been derived that mathematically describe the algorithms for performing the evaluation correction procedure using various forms of correction representation. The influence of the correction execution model on the characteristics of uncertainty in the independent evaluation result has been analyzed. The scope of two possible types of correction introduction models has been determined. A specific numerical example was used to demonstrate the methodological advantages of using a multiplicative model when summarizing percentage corrections. The independence of the correction result on the sequence of correction introduction has been confirmed. It is proposed to use the selected measure of partial corrections as a criterion for the adequacy of the correction introduction model. It is proved that the result of the independent expert evaluation depends on the chosen model and does not depend on the sequence of correction introduction. The reported study results are important in terms of theory and practice since they make it possible to improve the accuracy and reliability of the result of independent expert evaluation. (shrink)

The present essay took as its hypothesis the premise that the Metaphysical Neutrality proposed by Husserl since his initial studies needs to be recognized with methodological and analytical limits. In order to overcome this limit, a recovery of the Metaphysics and Theory of Knowledge of St. Thomas Aquinas was carried out, interpreting this theory through a Moderate and Direct Realism. As a conclusion, it was possible to identify that there is a very important similarity between both theories, as well as (...) that for phenomenological investigations to achieve their primary cognitive intent, care must be taken not to annihilate moderate realist metaphysics. (shrink)

In this thesis I examine the view—known as intellectualism—that knowledge-how is a kind of knowledge-that, or propositional knowledge. I examine issues concerning both the status of this view of knowledge-how and the philosophical implications if it is true. The ability hypothesis is an important position in the philosophy of mind that appeals to Gilbert Ryle’s famous idea that there is a fundamental distinction between knowledge-how and knowledge-that. This position appears to be inconsistent with the truth of intellectualism. However, I demonstrate (...) in this thesis that the ability hypothesis can be restated using the intellectualist view of knowledge-how. With regards to the status of intellectualism, I argue that the two main traditional arguments against intellectualism do not succeed. I also provide new and, I claim, successful arguments against intellectualism. These arguments point to a new view of knowledge-how that is distinct from both the standard intellectualist and Rylean views of knowledge-how. (shrink)

I argue that the contemporary interplay of cosmology and particle physics in their joint effort to understand the processes at work during the first moments of the big bang has important implications for understanding the nature of lawhood. I focus on the phenomenon of spontaneous symmetry breaking responsible for generating the masses of certain particles. This phenomenon presents problems for the currently fashionable Dretske-Tooley-Armstrong theory and strongly favors a rival nomic ontology of causal powers.

A critical discussion of Seumas Miller's view on knowing-how and joint abilities.

The success of deep learning in natural language processing raises intriguing questions about the nature of linguistic meaning and ways in which it can be processed by natural and artificial systems. One such question has to do with subword segmentation algorithms widely employed in language modeling, machine translation, and other tasks since 2016. These algorithms often cut words into semantically opaque pieces, such as ‘period’, ‘on’, ‘t’, and ‘ist’ in ‘period|on|t|ist’. The system then represents the resulting segments in a dense (...) vector space, which is expected to model grammatical relations among them. This representation may in turn be used to map ‘period|on|t|ist’ (English) to ‘par|od|ont|iste’ (French). Thus, instead of being modeled at the lexical level, translation is reformulated more generally as the task of learning the best bilingual mapping between the sequences of subword segments of two languages; and sometimes even between pure character sequences: ‘p|e|r|i|o|d|o|n|t|i|s|t’ → ‘p|a|r|o|d|o|n|t|i|s|t|e’. Such subword segmentations and alignments are at work in highly efficient end-to-end machine translation systems, despite their allegedly opaque nature. The computational value of such processes is unquestionable. But do they have any linguistic or philosophical plausibility? I attempt to cast light on this question by reviewing the relevant details of the subword segmentation algorithms and by relating them to important philosophical and linguistic debates, in the spirit of making artificial intelligence more transparent and explainable. (shrink)

Neural machine translation (NMT) is one of the success stories of deep learning and artificial intelligence. Revolutionary innovations in the computational architectures made in 2015–2017 have led to dramatic improvements in the quality of machine translation (MT) and changed the field forever. Some professional translators welcome these changes with enthusiasm, others less so. But everyone has to deal with them. Historically, the relationship between human translation and MT has been uneasy and complicated, but an increasing number of players in both (...) fields are now coming to view it as synergistic. -/- OPUS-CAT is a collection of machine translation software based on a Windows implementation of Marian NMT—a stable production-ready neural machine translation framework used in many industrial and research applications. It can be installed on your PC, fine-tuned to specialized translation domains, and integrated into CAT tools. (shrink)

En atención a las críticas de la autointerpretación teórica heideggeriana, abordaremos tres temas fundamentales posteriores al “giro” trascendental husserliano. A la luz de la interpretación contemporánea, buscaremos evitar los lugares comunes de la crítica a Husserl, en aras de una discusión más sofisticada en torno al método fenomenológico. /// Considering the most extended arguments of Martin Heidegger against the transcendental " turn " of Phenomenology, we will approach to three main characters of this sui generis transcendentalism. In light of contemporary (...) phenomenological studies, we will avoid commonplaces of misinterpretation in order to gain a more sophisticated debate about phenomenological method. (shrink)

The author’s studies in the philosophy of science, culminating in this book, were inspired by his previous research in the domains of classical and quantum gravity. In fact it was the need to bring some order in the family of modern classical theories of gravitation and to build up the appropriate conceptual foundations of quantum gravity , that forced the author to create his own methodological model of theory change, which he applies rather successfully to the most controversial case study, (...) the Lorentz-Einstein transition. (shrink)

This study aimed to identify the learning and business incubation processes and their impact on developing the performance of business incubators in Gaza Strip, and the study relied on the descriptive analytical approach, and the study population consisted of all employees working in business incubators in Gaza Strip in addition to experts and consultants in incubators where their total number reached (62) individuals, and the researchers used the questionnaire as a main tool to collect data through the comprehensive survey method, (...) where (55) questionnaires were retrieved with a recovery rate of (88.7%). The results of the study showed that there is a high approval of the variables of the study, where the dimension of incubation operations came with a relative weight (84.89%), followed by the learning dimension which got a relative weight (82.50%), while the performance level of the incubators got a relative weight (80.12%) and as the study results showed There is a positive relationship statistically between the two dimensions of learning and business incubation processes and performance development in business incubators, and the linear regression analysis model showed that the main effect in improving the performance of business incubators is "after business incubation operations" while it showed weak effect after learning. The study came out with several recommendations, the most important of which is that business incubators seek to reinforce the learning process and incubation processes for business, and the need to periodically evaluate their performance, and that a more effective mechanism be designed to follow up with companies after the end of the incubation period and monitor the progress of these companies. (shrink)

Background: With the coming of the Industrial Revolution, the levels of pollution grow significantly. This Technological development contributed to the worsening of shortness breath problems in great shape. especially in infants and children. There are many shortness breath diseases that infants and children face in their lives. Shortness of breath is one of a very serious symptom in children and infants and should never be ignored. Objectives: Along these lines, the main goal of this expert system is to help physician (...) in diagnosing and describe some common causes of shortness of breath in infants and children by diagnosing their cases through our expert system. Moreover, this system which we are presenting will give patient the appropriate diagnosis of disease and the treatment required. Methods: In this paper the strategy of the expert system for diagnosing a number of the existed shortness of breath in infants and children diseases such as (Asthma , Bronchiolitis, Viral Pneumonia, cough, Shortness of breath' dyspnea ', Epiglottitis, Croup, ABSCESS in the tonsil 'peritonsillar abscess', Bronchitis, Viral Bronchitis, Wheezing, sudden infant death syndrome 'SIDS' ) is introduced, an overview about the shortness of breath in children and infants diseases are delineated, the cause of diseases are sketched and the treatment of disease whenever conceivable is given . SL5 Object Expert System language was utilized for designing and implementing the proposed expert system. Results: The proposed shortness of breath in children and infants diseases diagnosis expert system was estimated by Medical students and they were satisfied with its result. Conclusions: The Proposed expert system is very useful for Respiratory physician, pediatrician, recently graduated physician, and for children's parents with shortness of breath problem. (shrink)

Ligado directamente a la dinámica de los movimientos renovadores del arte que surgieron en la España de los años veinte, el texto de Ortega y Gasset ofrece unas perspectivas más amplias y entronca con la renovación de la estética y la historia del arte que había iniciado la tradición teórica e historiográfica alemana a finales del siglo XIX. Ofrecemos, además otros escritos que, como «¿Una exposición Zuloaga?», «La Gioconda», «Diálogo sobre el arte nuevo», «Ensayo de estética a manera de prólogo» (...) y «Sobre la crítica del arte», permiten una mejor comprensión del pensamiento de Ortega y del debate artístico y estético en España. La presente edición va precedida de un prólogo de Valeriano Bozal. (shrink)

‘Substance’ (substantia, zelfstandigheid) is a key term of Spinoza’s philosophy. Like almost all of Spinoza’s philosophical vocabulary, Spinoza did not invent this term, which has a long history that can be traced back at least to Aristotle. Yet, Spinoza radicalized the traditional notion of substance and made a very powerful use of it by demonstrating – or at least attempting to demonstrate -- that there is only one, unique substance -- God (or Nature) -- and that all other things are (...) merely modes or states of God. Some of Spinoza’s readers understood these claims as committing him to the view that only God truly exists, and while this interpretation is not groundless, we will later see that this enticing and bold reading of Spinoza as an ‘acosmist’ comes at the expense of another audacious claim Spinoza advances, i.e., that God/Nature is absolutely and actually infinite. But before we reach this last conclusion, we have a long way to go. So, let me first provide an overview of our plan. In the first section of this paper we will examine Spinoza’s definitions of ‘substance’ and ‘God’ at the opening of his magnum opus, the Ethics. Following a preliminary clarification of these two terms and their relations to the other key terms defined at the beginning of the Ethics, we will briefly address the Aristotelian and Cartesian background of Spinoza’s discussion of substance. In the second section, we will study the properties of the fundamental binary relations pertaining to Spinoza’s substance: inherence, conception, and causation. The third section will be dedicated to a clarification of Spinoza’s claim that God, the unique substance, is absolutely infinite. This essential feature of Spinoza’s substance has been largely neglected in recent Anglo-American scholarship, a neglect which has brought about an unfortunate tendency to domesticate Spinoza’s metaphysics to more contemporary views. The fourth section will study the nature of Spinoza’s monism. It will discuss and criticize the interesting yet controversial views of the eminent Spinoza scholar, Martial Gueroult, about the plurality of substances in the beginning of the Ethics; address Spinoza’s claim in Letter 50 that, strictly speaking, it is improper to describe God as “one”; and, finally, evaluate Spinoza’s kind of monism against the distinction between existence and priority monism recently introduced into the contemporary philosophical literature. The fifth and final section will explain the nature, reality, and manner of existence of modes. We therefore have an ambitious plan; let’s get down to business. (shrink)

Objective: The nutrient artery which enters through the nutrient foramen (NF) provides blood circulation and nutrition in long bones. This supply is essential during the growing period, the early phases of ossification, and in some surgical procedures. This study aimed to investigate NF in adult human ulnas in the Turkish population. -/- Methods: For this study, 155 (70 right and 85 left) Turkish dry adult human ulnas were used. The presence, number, and patency of NF were recorded as well as (...) its topography and direction. The vertical distance between the most proximal point of the olecranon and the proximal edge of the NF (DONF), and the longitudinal distance between the most ventral point of the coronoid process on the sagittal plane and the proximal edge of the NF (DCpNF) was calculated. Additionally, the foraminal index (FI) was assessed. -/- Results: Single and double NFs were in 139 ulnas (89.67%), and 3 ulnas (1.94%), respectively. NFs were not observed in 13 ulnas (8.39%). The majority of NFs (93.12%) were situated on the anterior surface of the ulna. The direction of all NFs was towards the elbow. The mean DONF and DCpNF were 9.48 ± 1.57 cm, and 6.68 ± 1.44 cm, respectively. The FI was 37.45% in ulnas with a single NF, while it was 41.46% in ulnas with a double NF. -/- Conclusion: Our study has presented additional information such as the FI of ulnas with 2 NFs, and the distance between the coronoid process and NF in the Turkish population. (shrink)

Jonathan Y. Tsou examines and defends positions on central issues in philosophy of psychiatry. The positions defended assume a naturalistic and realist perspective and are framed against skeptical perspectives on biological psychiatry. Issues addressed include the reality of mental disorders; mechanistic and disease explanations of abnormal behavior; definitions of mental disorder; natural and artificial kinds in psychiatry; biological essentialism and the projectability of psychiatric categories; looping effects and the stability of mental disorders; psychiatric classification; and the validity of the DSM's (...) diagnostic categories. The main argument defended by Tsou is that genuine mental disorders are biological kinds with harmful effects. This argument opposes the dogma that mental disorders are necessarily diseases that result from biological dysfunction. Tsou contends that the broader ideal of biological kinds offers a more promising and empirically ascertainable naturalistic standard for assessing the reality of mental disorders and the validity of psychiatric categories. (shrink)

Is a human more conscious than an octopus? In the science of consciousness, it’s oftentimes assumed that some creatures (or mental states) are more conscious than others. But in recent years, a number of philosophers have argued that the notion of degrees of consciousness is conceptually confused. This paper (1) argues that the most prominent objections to degrees of consciousness are unsustainable, (2) examines the semantics of ‘more conscious than’ expressions, (3) develops an analysis of what it is for a (...) degreed property to count as degrees of consciousness, and (4) applies the analysis to various theories of consciousness. I argue that whether consciousness comes in degrees ultimately depends on which theory of consciousness turns out to be correct. But I also argue that most theories of consciousness entail that consciousness comes in degrees. (shrink)

This paper develops a theory of analog representation. We first argue that the mark of the analog is to be found in the nature of a representational system’s interpretation function, rather than in its vehicles or contents alone. We then develop the rulebound structure theory of analog representation, according to which analog systems are those that use interpretive rules to map syntactic structural features onto semantic structural features. The theory involves three degree-theoretic measures that capture three independent ways in which (...) a system can be more or less analog. We explain how our theory improves upon prior accounts of analog representation, provides plausible diagnoses for novel challenge cases, extends to hybrid systems that are partially analog and partially symbolic, and accounts for some of the advantages and disadvantages of representing analogically versus symbolically. (shrink)

This chapter examines the legacy of Kuhn’s Structure for normative philosophy of science. As an argument regarding the history of 20th century philosophy of science, I contend that the main legacy of Structure was destructive: Structure shifted philosophy of science away from addressing general normative philosophical issues (e.g., the demarcation problem, empirical testability) towards more deflationary and local approaches to normative issues. This is evident in the first generation of post-Structure philosophers of science in the 1980s and 1990s, who adopted (...) a pluralist approach to HPS. As a metaphilosophical argument regarding the methods adopted in HPS, I argue that there are a plurality of legitimate philosophical methodologies for inferring normative claims from historical cases. I frame this argument as a response to Pitt’s dilemma of case studies. I reject Pitt’s dilemma for its presupposition of an unrealistic and unfruitful standard (viz., epistemic certainty) for assessing HPS arguments and its analysis of philosophical methodology at the level of individual arguments. Pitt’s dilemma is most usefully understood as identifying potential points of criticism for HPS arguments. -/- The chapter begins with an examination of Kuhn’s normative philosophy of science in Structure and his position that historical cases provide evidence for philosophical claims. Kuhn’s philosophical methodology is insufficiently articulated, and his utilization of case studies is subject to objections (viz., interpretative bias, hasty generalization) implied by Pitt’s dilemma. I subsequently examine four post-Kuhnian methodological perspectives: (1) Ian Hacking’s particularism, (2) Helen Longino’s practice-based approach, (3) Michael Friedman’s neo-Kantianism, and (4) Hasok Chang’s complementary science. These views suggest alternative methodological strategies in HPS for addressing normative issues. I conclude by articulating some outstanding methodological challenges for the pluralist tradition of HPS—associated with the Stanford and Minnesota schools of philosophy of science—that emerged in the 1980s and remains influential. (shrink)

INTRODUCTION[|]It can be thought that ethical problems will rise as the population gets older. Issues such as competence and autonomy of the elderly are among the rising ehtical problems. The fact people aged 65 and over are being questioned about their competence, is an ethical problem in Turkey and this issue is discussed in this work. [¤]METHODS[|]Many institutions subject people over 65 to adequacy audit in decision making stage and this is repeated for every new situation. As a result of (...) this, people over 65 have to be examined by a doctor although there isn't a medical condition. This problem has been discussed within the framework of the following questions: 'In what extent is it legitimate to question the adequacy of a person aged over 65? How does a person feel when her/his adequacy is questioned? Can she/he be the same person as she/he feels before? When does being and individual or adequacy of a person disappear? And, who can decide in this issue?' [¤]RESULTS[|]-[¤]DISCUSSION AND CONCLUSION[|]It has been thought that autonomy of people over 65 years is violated partly and being over 65 years is perceieved as an abnormal situation. [¤]. (shrink)

Much of the contemporary thought about ecology begins with the questioning of the human exceptionality. By means of this, anthropocentrism is rejected and replaced by a post-humanist framework. In this context, Martin Heidegger‘s oeuvre is credited for its search of alternatives to humanism, particularly because of its rejection of Sartre‘s anthropocentrism. However, while post-humanisms tend to behold the role of technology positively, Heidegger‘s critiques to the technique as a consequence of the same metaphysical and anthropocentric movement are widely known. Instead (...) of considering the common Heideggerian texts about technique, in this paper I explore the relationship between Heidegger and contemporary post-humanisms from the perspective of his existential analytic. In the first place, I will briefly describe the contemporary techno-scientific context, following the insights of Wiener, Haraway and Latour. In the second place, I will consider the relationship between Dasein, cyborgs and animals, discussing the Heideggerian interpretations of Hubert Dreyfus (What Computers Can’t Do) and Steven Crowell (We Have Never Been Animals). (shrink)

In psychiatry, pharmacological research has played a crucial role in the formulation, revision, and refinement of neurobiological theories of psychopathology. Besides being utilized as potential treatments for various mental disorders, pharmacological drugs play an important epistemic role as experimental instruments that help scientists uncover the neurobiological underpinnings of mental disorders (Tsou, 2012). Interventions with psychiatric patients using pharmacological drugs provide researchers with information about the neurobiological causes of mental disorders that cannot be obtained in other ways. This important source of (...) evidence for the biological causes of mental disorder is often overlooked in philosophical analyses of psychiatry, especially in skeptical analyses that debase the biological aspects of psychopathology (e.g., Szasz, 1960; Scheff, 1963; Laing, 1967). In discussing pharmacological interventions as a form of evidence for the physical basis of mental disorders, this paper aims to clarify the nature, reliability, and limitations of this evidence. In addition, it illustrates the central role that pharmacological findings in applied clinical contexts play in the acquisition of neurobiological knowledge in research contexts. (shrink)

A phenome occurs through the many pathways of the complex net of interaction between the phenome and its environment; therefore researching and understanding how it arises requires investigation into many possible causes that are in constant interaction with each other. The most comprehensive investigations in biology are the ones in which many biologists from different sub-areas—evolutionary biology, developmental biology, molecular biology, physiology, genetics, epigenetics, ecology—have collaborated. Still, biologists do not always need to collaborate or look for the most comprehensive explanations. (...) A more standard investigation in biology occurs within a single subarea, and uses well-defined experiments with very specific conditions. This paper is about causation and related explanation in plant phenome research and its relevance to Aristotle’s Theory of Four Causes. I argue that there are causes which resemble Aristotle’s formal, material, and efficient causes in phenotype explanation and occurrence; but causes which resemble Aristotle’s final causes occur in phenotype explanation only, not in the occurrence. (shrink)

This paper examines the idea of "objective phenomenology," or a way of understanding the phenomenal character of conscious experiences that doesn’t require one to have had the kinds of experiences under consideration. My central thesis is that structural facts about experience—facts that characterize purely how conscious experiences are structured—are objective phenomenal facts. I begin by precisifying the idea of objective phenomenology and diagnosing what makes any given phenomenal fact subjective. Then I defend the view that structural facts about experience are (...) objective. I also argue that structural facts about experience, despite being objective, nevertheless still give rise to an explanatory gap. (shrink)

Conscious experiences are characterized by mental qualities, such as those involved in seeing red, feeling pain, or smelling cinnamon. The standard framework for modeling mental qualities represents them via points in geometrical spaces, where distances between points inversely correspond to degrees of phenomenal similarity. This paper argues that the standard framework is structurally inadequate and develops a new framework that is more powerful and flexible. The core problem for the standard framework is that it cannot capture precision structure: for example, (...) consider the phenomenal contrast between seeing an object as crimson in foveal vision versus merely as red in peripheral vision. The solution I favor is to model mental qualities using regions, rather than points. I explain how this seemingly simple formal innovation not only provides a natural way of modeling precision, but also yields a variety of further theoretical fruits: it enables us to formulate novel hypotheses about the space and structures of mental qualities, formally differentiate two dimensions of phenomenal similarity, generate a quantitative model of the phenomenal sorites, and define a measure of discriminatory grain. A noteworthy consequence is that the structure of the mental qualities of conscious experiences is fundamentally different from the structure of the perceptible qualities of external objects. (shrink)

Some philosophers think that life is worth living not merely because of the goods and the bads within it, but also because life itself is good. I explain how this idea can be formalized by associating each version of such of a view with a function from length of life to the value generated by life itself. Then I argue that every version of the view that life itself is good faces some version of the following dilemma: either (1) good (...) human lives are worse than very long lives wholly devoid of pleasure, desire-satisfaction, knowledge, or any other goods, or (2) very short lives containing nothing but suffering are worth living. Since neither result is plausible, we ought to reject the view that life itself is good. On the view I favor, any given life may be worth living because of the goods that it contains, but life itself is neutral. (shrink)

Abstract— Anatomy of the anterior compartment includes the tibia and the fibula. It also includes the tibialis anterior tendon, the extensor hallucis longus tendon and the extensor digitorum longus tendons. The anterior tibial artery and the deep peroneal nerve and finally the superior and inferior extensor retinaculum. In this paper an expert system was designed to help users to correctly diagnose ankle problems. There are many structures present at the anterior aspect of the ankle; these structures are often susceptible to (...) injury common injuries and conditions around the anterior ankle. Clips expert system language was used to design and implement this expert system. (shrink)

Anadolu’da doğan ve yaşayan doğa bilimcileri ve filozofları Sokrates öncesi düşünce dünyasını yansıtmaktadırlar. Düşünce ve teoriler üretmekte kendilerine göre bir sistem oluşturmuşlardır. Antik dönemde doğa olaylarının kişileştirilip tanrılarla simgelenmesini ve söylencelerle yaygınlaşıp geliştirilmesini, onlara tapınılmasını (pagan tanrılarını) kabul etmeyen bireysel çıkışlar olarak başkaldırmışlardır. M.Ö. 5. yüzyılda Atina’da Yunan Uygarlığı’nın klasik çağına ve doruk noktasına geçişlerinde Anadolu’daki Pers saldırılarından kaçan İyonyalı düşünürlerin ve sanatçıların da rolü bulunmaktadır.

Reseña en español del diálogo entre A. Badiou y J.-L. Nancy, editado por Jan Völker y publicado en 2017.

Is consciousness intrinsically valuable? Some theorists favor the positive view, according to which consciousness itself accrues intrinsic value, independent of the particular kind of experience instantiated. In contrast, I favor the neutral view, according to which consciousness is neither intrinsically valuable nor disvaluable. The primary purpose of this paper is to clarify what is at stake when we ask whether consciousness is intrinsically valuable, to carve out the theoretical space, and to evaluate the question rigorously. Along the way, I also (...) show why the neutral view is attractive and why certain arguments for the positive view do not work. (shrink)

Many philosophers accept both of the following claims: (1) consciousness matters morally, and (2) species membership doesn’t matter morally. In other words, many reject speciesism but accept what we might call 'sentientism'. But do the reasons against speciesism yield analogous reasons against sentientism, just as the reasons against racism and sexism are thought to yield analogous reasons against speciesism? This paper argues that speciesism is disanalogous to sentientism (as well as racism and sexism). I make a case for the following (...) asymmetry: (a) some non-humans clearly have interests, but (b) no non-conscious entities clearly have interests. This asymmetry, I argue, renders sentientism resistant to the standard argument against speciesism. (shrink)

Artificial intelligence is one of the most rapidly evolving fields today. It is used in the majority of computer science applications nowadays. Expert systems are one of the most valuable types of AI; they are used to deliver predictions and decisions in order to make scientific, medical, and even architectural challenges easier to address; they will eventually take the place of a human expert. Without having to meet with a genuine human specialist, the user will be able to get a (...) precise solution or diagnose to his problem. This study provides an illustration of how computer systems can be used in agriculture. In order to construct an expert system that can forecast a disease based on its symptoms, we chose a Coriander plant and five of its recognized ailments. CLIPS was used to develop the system. This article contains a full summary of the work that has been done. (shrink)